The Federal Court of Appeals for the 2nd Circuit reversed the trial court decision to determine the invalidity of Brazilian patent PI 9708108-6, owned by Sanofi-Aventis (case Cristalia Ltda v. Sanofi-Aventis Deutschland Gmbh). This patent claimed a combination of leflunomide and teriflunomide. The decision was published on August 24, 2018. In 2015, the Brazilian generic…